In its first global guideline on childhood obesity, the WHO says medicines such as GLP-1 drugs should be considered only for adolescents, and only after a supervised lifestyle program has not worked. No drugs or surgery for children nine and under.
Lupus can affect almost any organ, looks different in every patient, and is often diagnosed late. A plain-language guide to the disease, the kidney complication doctors watch for, today’s treatments and why some are so expensive.
For stage III colon cancers with a DNA-repair defect, adding the immunotherapy to standard chemotherapy halved the risk of the cancer returning. It is the first immunotherapy combination approved for use after surgery in this setting.
Gene therapy adds a working gene; gene editing rewrites the one you have. A plain-language guide to how each works, what is already approved, what they cost, and the risks that still limit them.
Adding paricalcitol, a prescription vitamin D analog, to standard chemotherapy raised the tumor response rate from 9% to 42% in 36 patients. It works not on the cancer cells but on the scar-like shield around them.
ai3Bio, formed from two startups and backed with $48 million, is developing an mRNA treatment that tells inflammatory Th17 cells to self-destruct. It is early — animal data only — but it targets a different culprit from most “immune reset” efforts.
It is one of the most common autoimmune diseases, and one of the slowest to be diagnosed. A plain-language guide to what Sjögren’s is, how it is found, how it is managed today, and the new drugs in late-stage trials.
People with higher blood levels of imidazole propionate, which gut microbes make from a common amino acid, showed more Alzheimer’s-related brain changes and faster cognitive decline. In mice, the molecule worsened the disease directly.
The Swiss drugmaker is paying China’s Abogen $575 million upfront for an injected mRNA that makes a B-cell-killing T-cell engager inside the patient — a possible simpler route to the “immune reset” that CAR-T promised for autoimmune disease.
The Autus valve can be widened with a balloon catheter as a child grows, from toddler size to adult size — sparing some children born with heart defects from repeated open-heart surgeries.
CAR-T turns a patient’s own immune cells into a living drug. It has transformed some blood cancers and is now being tested in lupus and multiple sclerosis. A plain-language guide to the process, the risks and what comes next.
From rheumatoid arthritis to eczema and alopecia, JAK inhibitors are among the most versatile drugs in immunology. A plain-language guide to how they work, the main ones, and why they carry a boxed warning.