Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome – a cell's complete set of DNA – is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.
Researchers at Washington University School of Medicine in St. Louis have identified a previously unknown signaling pathway cells use to protect their DNA while it is being copied.