Roche Bets $2.5B on an Obesity Drug That Aims to Spare Muscle
GLP-1 drugs strip muscle along with fat, and the industry has decided that is the next problem to solve. Roche paid $190M upfront for a Phase 1 asset aimed at it.
About 1 in 14 US children has a speech disorder and roughly 40% get no support. Amazon’s pitch is not new therapy capacity — it is telling people the benefit they already have exists.
GLP-1 drugs strip muscle along with fat, and the industry has decided that is the next problem to solve. Roche paid $190M upfront for a Phase 1 asset aimed at it.
Not an acquisition — an incubator place. Lilly gets a window onto an RNA platform without buying it, and Rznomics gets lab space and US infrastructure it would take years to build.
Antibiotics reshaping gut bacteria is expected. Benzodiazepines doing it to a comparable degree is not — and the effects were still detectable years after people stopped.
Masses on the spines of five patients treated three to six years ago. All asymptomatic, nature unconfirmed — and the second hold on a Regenxbio programme this year.
An 83.4% reduction in the risk of progression or death is an unusual number. Over 90% of patients progression-free at six months were still progression-free at three years.
Half a million DNA variants, measured for activity, then fed to a machine-learning model. The result: the sequence signature marking where a gene starts — found in about 60% of human genes.
Soda purchases fell 12% where SNAP restricted them. Up to 39% of the money moved to other sugary drinks the rules did not cover — which is the finding policymakers should read.
APOE4 raises Alzheimer’s risk and nobody could say how. Gladstone researchers found it drives one protein up inside neurons — and lowering that protein in adult mice reversed the damage.
Five years, 1,300 patients, 500 enrolled in Johns Hopkins trials — without leaving central Pennsylvania. The trial access is the part that is hard to replicate.
Two vaccines, 12,717 participants, 38 months. Some real protective signals in specific groups — and no protection at all in underweight people, which is where TB concentrates.
Fifty-two injections a year instead of 365. NICE recommended it on equivalence rather than superiority — because for insulin, the same control with fewer injections is the improvement.